本部分收集展示了缅甸近期在全球公共卫生领域的研究进展，具体如下：

Authors	Article Title	文章标题	Source Title	Abstract	摘要	Publication Year	DOI Link
Oo, AT; Chen, H	Situational Analysis of Malaria Incidence Under Integrated Malaria Service in Hotspot Township - Minbya Township, Rakhine State, Myanmar, 2017-2020	2017-2020年缅甸若开邦敏比亚镇这一疟疾高发乡镇在综合疟疾服务下的疟疾发病情况分析	CHINA CDC WEEKLY	Introduction : Malaria is a significant public health concern and tropical disease, particularly affecting Myanmar within the Greater Mekong Subregion. The annual parasite index (API) exceeds 1 per 10,000 population in the northern seven townships of Rakhine State, with Minbya Township designated as a highburden area for malaria by the World Health Organization (WHO) Myanmar and the National Malaria Control Programme (NMCP). Since 2017, the Malaria reduction intensification plan has been in place in this township to combat the high disease transmission rates. This study aims to assess the malaria epidemiology in Minbya Township from 2017 to 2020 under the intensification plan for elimination, as well as to evaluate the effectiveness of the integrated strategy in reducing cases in hotspot areas. Methods : The study utilized a surveillance study design to collect secondary data from the Malaria surveillance system (MSS) and the epidemiologic monitoring dashboard of Minbya Township, Maruk-U District, located in Rakhine State. Results : Since 2017, the Malaria prevention and control (P&C) Program in Minbya Township has successfully decreased malaria morbidity, eliminated malaria -related deaths, and bolstered malaria testing capabilities through the participation of village health volunteers (VHVs). Approximately 87 % of malaria prevention and control services are executed by the township's malaria elimination and disease control programs, with additional support from stakeholders. The API dropped from 13 in 2017 to 2.5 in 2020, with Plasmodium vivax being the most prevalent malaria species, accounting for 55 % of cases. Conclusions : The study suggests that early diagnosis and promotion of artemisinin-based combination treatment (ACT), along with strategic planning including expanding active case detection in rural health centers and implementing a community based integrated healthcare approach, are effective and efficient strategies for malaria elimination.	本研究旨在评估缅甸若开邦敏比亚镇区在2017至2020年实施疟疾强化消除计划期间的流行病学特征及综合策略的有效性。结果显示，通过疟疾预防与控制计划，当地发病率和死亡病例显著下降，检测能力通过乡村卫生志愿者的参与得到提升。年度寄生虫指数从较高水平降至较低水平，间日疟原虫成为主要虫种，占病例半数以上。研究结论指出，早期诊断、推广青蒿素联合疗法、扩大农村卫生中心的主动病例检测以及实施基于社区的整合医疗保健方法，是实现疟疾消除的有效且高效策略。	2024	http://dx.doi.org/10.46234/ccdcw2024.072
Lin, ZR; Yin, SS; Yang, J; Guo, XR; Dong, CL; Lin, YK; Ding, CL; Sun, XD; Yan, RX; Yang, SL; Zhou, XH; Xu, JW	The public health response to an outbreak of border-spill malaria along China-Myanmar border	中国与缅甸边境地区跨境疟疾暴发的公共卫生应对	PLOS ONE	Introduction Malaria importation can be caused by cross-border movement either of both people and anopheline mosquitoes. However, there still lacks robust evidence of imported malaria caused by Plasmodium spp. infected anopheles along international border areas (border-spill malaria). The objectives of this study were to confirm whether an outbreak of Plasmodium vivax malaria is border-spill malaria and assess the effects of China's public health response along China-Myanmar border. Methods Epidemiological, parasitological and entomological investigations were conducted to investigate the outbreak of border-spill malaria. Meanwhile, comprehensive interventions were carried out to prevent further transmission and reintroduction of malaria. Results Rapid diagnostic testing, microscopy and polymerase chain reaction were performed and the infections were confirmed as P. vivax. A total of 22 (9.21%) of 239 workers contracted P. vivax during the outbreak. Multivariate logistic regression analysis identified that the distance of worker shelters in China within 300 meters to the internally displaced person (IDP) camps in Myanmar was a risk factors associated with malaria infection (adjusted odds ratio 7.5920; 95% confidence interval, 2.6079-22.1013; P = 0.0002). After comprehensive interventions, malaria transmission was successfully interpreted and prevented at the project site till the completion of project on 14 January 2020, and recurrence of P. vivax malaria was not detected by the end of 2020. Conclusion This study provided robust evidence of border-spill malaria along China-Myanmar border. Malaria parasite reservoir and distance travelled by female anopheline mosquitoes are two determinants for border-spill malaria. The public health response to the outbreak indicates that the malaria surveillance and response system works well in preventing reintroduction of malaria. However, prevention of border-spill malaria is still a major challenge in the Yunnan border area, China.	本研究旨在确认中缅边境一起间日疟疫情是否为跨境输入性疟疾，并评估中国的公共卫生应对效果。通过流行病学、寄生虫学和昆虫学调查，确认感染为间日疟，疫情波及在边境中国侧工作的多名工人。多因素分析显示，工人宿舍与缅甸境内流离失所者营地之间的距离是感染的重要危险因素。经综合干预后，疫情得以成功阻断，至项目结束及年底均未再检测到间日疟复发。研究为边境输入性疟疾提供了有力证据，指出疟原虫储存库和雌性按蚊的飞行距离是决定跨境输入性疟疾的两个关键因素。尽管中国的监测与响应体系有效防止了疟疾再传播，但预防边境输入性疟疾仍是中国云南边境地区面临的主要挑战。	2022	http://dx.doi.org/10.1371/journal.pone.0275932
Bai, LY; Zhang, DD; Liu, Y; Yang, XF; Lu, CH	Investigation on the anti-T3SS activity of Myanmar vegetables and identification of arjunglucoside II as a T3SS inhibitor from Ludwigia adscendens	缅甸蔬菜抗III型分泌系统活性研究及从Ludwigia adscendens中鉴定出的arjunglucoside II作为T3SS抑制剂	JOURNAL OF FUTURE FOODS	Vegetables are not only important dietary components in maintaining our daily life, but also potential resources for healing diseases. Myanmar is endowed with diverse vegetable species and many are also used as traditional medicines. In this study, we investigated 48 vegetable samples from central Myanmar for their inhibitory activities against the type III secretion system (T3SS) of Salmonella enterica serovar Typhimurium, one of the most prevalent pathogenic bacteria that causes infections. Results showed that 15 vegetables exhibited moderate to strong inhibitory activities against the secretion of T3SS effector proteins, providing the scientific evidence for the traditional knowledge of vegetables and their potential pharmacological function. By detailed chemical investigation, we found the vegetables, i.e., Archidendron jiringa (Jack) Nielsen., Neptunia plena (Linn.) Benth. and Ludwigia adscendens (L.) Hara have the potential for discovering the components with anti-T3SS activity. Bioassay-guided isolation of L. adscendens led to identify arjunglucoside II as anew T3SS inhibitor. (c) 2026 The authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).	本研究发现，缅甸中部多种蔬菜对沙门氏菌III型分泌系统具有抑制作用。在48种蔬菜样本中，有15种表现出中到强效的抑制活性，为这些蔬菜的传统药用价值提供了科学依据。其中，臭豆、美洲水合欢和草龙三种蔬菜在发现抗T3SS活性成分方面具有潜力。通过生物活性导向分离，从草龙中鉴定出一种新的T3SS抑制剂	2026	http://dx.doi.org/10.1016/j.jfutfo.2024.05.011
Win, TTZ; Campbell, A; Magalhaes, RS; Oo, KN; Henning, J	Perceptions of livestock value chain actors (VCAs) on the risk of acquiring zoonotic diseases from their livestock in the central dry zone of Myanmar	缅甸中部干旱区养殖业者（VCAs）对从牲畜中感染人畜共患病风险的认知	BMC PUBLIC HEALTH	ObjectivesThe Central Dry Zone (CDZ) is one of the most important livestock production areas of Myanmar. However, there is an eminent lack of information on the attitudes and traditional beliefs of local farmers and livestock supply chain actors in CDZ of Myanmar on the public health implications. A modified data collection instrument of the Health Belief model was developed to investigate attitudes, beliefs and barriers to the application of recommended zoonotic disease prevention.Study designCross-sectional study.MethodData analyses were conducted considering a two-phase multilevel mixed effect binomial generalized linear models modelling approach.ResultsThe availability of information about zoonosis to supply chain actors influenced their confidence to implement preventive actions (OR = 1.5, p = 0.045 for cattle diseases; OR = 1.5, p = 0.022 for village chicken diseases). Supply chain actors were more likely aware of zoonosis transmitted by cattle compared to livestock farmers (OR = 0.3, p = 0.005 for cattle farmers), while people not rearing or trading small ruminants and/or poultry were less likely to be aware of the zoonotic risk associated with these animals (p < 0.005). Information on zoonosis transmitted from small ruminants was mainly promoted through farmers (p = 0.032), while information on zoonotic diseases that can be obtained from chickens was disseminated through farmers, local authorities and the media. Nevertheless, appropriate hand hygiene measures (i.e. cleaning of hands after touching, cutting, cooking meat) (OR = 7.7, p < 0.001 for zoonotic small ruminant diseases; OR = 1.6, p = 0.073 for zoonotic village chicken diseases) and treating of sick animals (OR = 7.3, p < 0.001 for small ruminant zoonotic diseases; OR = 2.2, p = 0.031 for village chicken zoonotic diseases) increased the confidence of small ruminant and village chicken owners to prevent these zoonotic infections.ConclusionsThe findings from this study indicate that while gender and the availability of information on zoonotic risks play an important role on the perceived threat of zoonoses, the practice of prevention methods influenced the confidence of value chain actors (VCAs) on zoonoses prevention.	本研究旨在调查缅甸中央干旱区农户及牲畜供应链参与者对人兽共患病预防的态度、传统观念和障碍。基于健康信念模型的数据分析显示，信息的可获得性显著影响了供应链参与者实施预防措施的信心。与农户相比，供应链参与者对牛传播人兽共患病的认知更高；不饲养或交易小反刍动物或家禽的人群对相关风险的认知较低。关于小反刍动物人兽共患病的信息主要通过农户传播，而禽类相关信息的传播渠道则包括农户、地方当局和媒体。采取适当的手卫生措施和对患病动物进行治疗，显著增强了小反刍动物和家禽饲养者预防人兽共患感染的信心。研究结论指出，性别和人兽共患病信息的可获得性影响了对疾病威胁的感知，而实际采取预防措施则直接影响了价值链条参与者对人兽共患病预防的信心。	2023	http://dx.doi.org/10.1186/s12889-022-14968-y
Kapandji, M; Lin, H; Mutua, MM; Xu, Q; Oshiro, R; Ibrahim, CHO; Pillay, MT; Yamasato, K; Nwe, KM; Raekiansyah, M; Dumre, SP; Thant, KZ; Aung, WW; Khin, AA; Thu, HM; Urano, T; Morita, K; Takamatsu, Y; Tun, MMN	Chikungunya virus in dengue-suspected patients: Molecular evidence from the 2019 outbreak in Yangon, Myanmar	登革热疑似患者中的PChikungunya病毒：来自缅甸仰光2019年疫情的分子证据	PLOS NEGLECTED TROPICAL DISEASES	Background Chikungunya virus (CHIKV) and dengue virus (DENV) frequently co-occur in Myanmar and present with overlapping symptoms, complicating diagnosis. During the 2019 dengue outbreak in Yangon, Myanmar, molecular data on CHIKV were limited among dengue-suspected patients and there were no publicly available CHIKV genome sequences from Yangon in international databases. To address this gap and potential diagnostic overlap, we investigated the prevalence of CHIKV infection and described the genomic characteristics of detected strains.Methods Serum samples from 267 dengue-suspected patients collected in 2019 were screened for anti-CHIKV IgM and IgG by in-house ELISA and 211 samples with sufficient remaining volume were further analyzed by RT-qPCR, isolation of the virus, and whole-genome sequencing for mutation analysis.Results CHIKV antibodies were found in 24.7% (66/267) of samples (IgM 3.4%, IgG 21.3%), and viral RNA was detected in 10.9% (23/211) of samples. Fifteen viral isolates were successfully obtained (7.1% of those tested), including two co-detections with DENV-2 by RT-PCR. All isolates belonged to the East/Central/South African genotype, Indian Ocean Lineage (ECSA-IOL), and clustered with strains from Thailand, China, and Mandalay, Myanmar. Whole-genome analysis identified 33 non-synonymous mutations across nonstructural and structural proteins, including mutations previously reported in regional ECSA-IOL strains such as E1:K211E and E2:V264A, with 11 amino acid changes not previously reported in available Myanmar reference sequences.Discussion Serological and molecular findings indicate CHIKV circulation during the 2019 dengue outbreak in Yangon and highlight the limitations of single-target testing. Serological evidence indicate the presence of anti-CHIKV IgM and IgG antibodies, reflecting CHIKV exposure within the study population. Notably, all RNA-positive cases were seronegative for both IgM and IgG, a pattern consistent with the temporal dynamics of infection and the inherent constraints of serological detection in co-endemic settings. Molecular co-detection with DENV-2 and genomic findings highlight the potential value of multiplex diagnostic approaches in co-endemic settings.Conclusion This study documents CHIKV detection and genomic characterization in dengue-suspected patients in Yangon and highlights the potential value of multiplex diagnostic approaches and continued genomic surveillance as broader public health considerations for arboviral detection in Myanmar.	本研究旨在调查2019年仰光登革热疫情期间基孔肯雅病毒的流行情况及其基因组特征。对登革热疑似患者的血清样本进行检测，发现抗体阳性率近四分之一，病毒RNA检出率约十分之一。成功获得多个病毒分离株，均为东/中/南非基因型印度洋谱系，与泰国、中国及缅甸曼德勒的毒株聚类。全基因组分析共鉴定出多个非结构蛋白和结构蛋白中的非同义突变，其中包括该谱系中先前报道的突变以及缅甸参考序列中未报道的氨基酸变化。值得注意的是，所有RNA阳性病例均表现为抗体阴性，反映了合并流行背景下血清学检测的时间局限性。本研究还发现了基孔肯雅病毒与登革热病毒2型的共感染。结论指出，在缅甸，对登革热疑似患者进行多重病原体检测和持续基因组监测具有重要的公共卫生价值。	2026	http://dx.doi.org/10.1371/journal.pntd.0014258
Wei, XY; Malla, P; Wang, ZL; Yang, ZQ; Cao, YM; Wang, CQ; Cui, LW	Genetic diversity of Plasmodium vivax population in northeast Myanmar assessed by amplicon sequencing of PvMSP1 and PvMSP3α	通过PvMSP1和PvMSP3α的扩增子测序评估缅甸东北部间日疟原虫种群的遗传多样性	ACTA TROPICA	This study aimed to assess the baseline genetic diversity of the Plasmodium vivax population in an endemic area of northeast Myanmar at the onset of the malaria elimination campaign in the Greater Mekong Subregion. We genotyped 125 P vivax clinical samples at two merozoite surface protein loci, PvMSP1 and PvMSP3 alpha, by amplicon deep sequencing. Our study revealed that the parasite population in this region was highly diverse, identifying 60 PvMSP1 and 98 PvMSP3 alpha haplotypes, with haplotype diversity of 0.929 and 0.944, respectively. Remarkably, 97.6 % (122/125) of the patients harbored multiclonal infections with a mean multiplicity of infection of 4.18, indicating a relatively high transmission intensity. Neutrality tests and network analysis suggested a recent parasite population expansion, consistent with the concurrent malaria outbreak in the region. These findings underscore the existence of a highly diverse P. vivax population at the China-Myanmar border, highlighting the need for effective malaria control strategies to achieve the goal of regional malaria elimination.	本研究旨在评估缅甸东北部间日疟原虫种群的基线遗传多样性。通过对临床样本进行高通量测序分析，发现该地区寄生虫种群高度多样化，共鉴定出大量PvMSP1和PvMSP3α单倍型，单倍型多样性水平极高。值得注意的是，绝大多数患者存在多克隆感染，平均感染复数较高，表明传播强度相对较高。中性检验和网络分析提示近期寄生虫种群呈扩张趋势，这与该地区同时发生的疟疾疫情相一致。研究结论强调，中缅边境存在高度多样化的间日疟原虫种群，需实施有效的疟疾控制策略以实现区域消除目标。	2024	http://dx.doi.org/10.1016/j.actatropica.2024.107461
Zhao, Y; Aung, PL; Ruan, SS; Win, KM; Wu, ZF; Soe, TN; Soe, MT; Cao, YM; Sattabongkot, J; Kyaw, MP; Cui, LW; Menezes, L; Parker, DM	Spatio-temporal trends of malaria incidence from 2011 to 2017 and environmental predictors of malaria transmission in Myanmar	2011年至2017年疟疾病例的时空趋势及缅甸疟疾传播的环境预测因素	INFECTIOUS DISEASES OF POVERTY	Background Myanmar bears the heaviest malaria burden in the Greater Mekong Subregion (GMS). This study assessed the spatio-temporal dynamics and environmental predictors of Plasmodium falciparum and Plasmodium vivax malaria in Myanmar. Methods Monthly reports of malaria cases at primary health centers during 2011-2017 were analyzed to describe malaria distribution across Myanmar at the township and state/region levels by spatial autocorrelation (Moran index) and spatio-temporal clustering. Negative binomial generalized additive models identified environmental predictors for falciparum and vivax malaria, respectively. Results From 2011 to 2017, there was an apparent reduction in malaria incidence in Myanmar. Malaria incidence peaked in June each year. There were significant spatial autocorrelation and clustering with extreme spatial heterogeneity in malaria cases and test positivity across the nation (P < 0.05). Areas with higher malaria incidence were concentrated along international borders. Primary clusters of P. falciparum persisted in western townships, while clusters of P. vivax shifted geographically over the study period. The primary cluster was detected from January 2011 to December 2013 and covered two states (Sagaing and Kachin). Annual malaria incidence was highest in townships with a mean elevation of 500-600 m and a high variance in elevation (states with both high and low elevation). There was an apparent linear relationship between the mean normalized difference vegetative index and annual P. falciparum incidence (P < 0.05). Conclusion The decreasing trends reflect the significant achievement of malaria control efforts in Myanmar. Prioritizing the allocation of resources to high-risk areas identified in this study can achieve effective disease control.	本研究分析了2011至2017年间缅甸疟疾的时空动态及环境预测因子，重点关注恶性疟和间日疟。结果显示，缅甸疟疾发病率在此期间显著下降，每年6月为发病高峰。全国范围内存在显著的空间自相关和聚集性，疟疾病例和检测阳性率呈现极端空间异质性，高发病率区域集中分布于国际边境地区。恶性疟的原发性聚集区持续存在于西部乡镇，而间日疟的聚集区在研究中呈现地理位移。年平均发病率最高出现在平均海拔500-600米且海拔差异较大的乡镇。归一化植被指数与恶性疟年发病率存在显著线性关系。研究结论表明，缅甸疟疾防控工作取得了显著成效，建议将资源优先配置于本研究识别出的高风险区域，以实现有效疾病控制。	2023	http://dx.doi.org/10.1186/s40249-023-01055-6
Fan, XY; Ning, K; Ma, TSW; Aung, Y; Tun, HM; Zaw, PPT; Flores, FP; Chow, MSC; Leung, CMC; Lun, P; Chang, WC; Leung, GM; Ni, MY	Post-traumatic stress, depression, and anxiety during the 2021 Myanmar con fl ict: a nationwide population-based survey	2021年缅甸冲突期间的创伤后应激障碍、抑郁和焦虑：一项全国性人群调查	LANCET REGIONAL HEALTH - SOUTHEAST ASIA	Background The UN warns that Myanmar faces the ' triple crises ' of mass con fl ict, uncontrolled COVID-19, and economic collapse. Therefore, we aimed to assess the population mental health burden, healthcare needs, and the associated risk factors in Myanmar. Methods We established a nationwide random sample and recruited 1038 adults via random digit dialling from July 3 - Aug 9, 2021, during the ongoing con fl ict since Feb 1, 2021, and surge in SARS-CoV-2 infections. Probable post -traumatic stress disorder (PTSD) was assessed using the PTSD Checklist - Civilian Version. Probable depression and anxiety were assessed using the Patient Health Questionnaire -2 and the Generalized Anxiety Disorder -2. We calculated population attributable fractions for probable mental disorders using multivariable logistic regression models. Based on the mental health burden and healthcare -seeking patterns, we projected the need for mental health services. Findings During the ' triple crises ' , a third of adults in Myanmar (34.9%, 95% CI 32.0 - 37.7) reported a probable mental disorder. Prevalence of probable PTSD, depression, and anxiety were 8.1% (6.6 - 9.7), 14.3% (12.0 - 16.6), and 22.2% (19.7 - 24.7), respectively. We estimated that up to 79.9% (43.8 - 97.9) of probable PTSD was attributable to political stress. This corresponds to 2.1 million (1.1 - 3.2 million) fewer adults with probable PTSD if political stress was removed from the population. The mental health burden could translate into roughly 5.9 million adults seeking mental health services. Interpretation The mental health burden in Myanmar is substantial, and population mental health might only be restored when the three crises have ended. An accelerated peace process is critical to protecting Myanmar ' s population mental health. Funding This research was supported the Research Grants Council of the Hong Kong Special Administrative Region, China (Project No. HKU 17606122) and the Michele Tansella Award. Copyright (c) 2024 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY -NC -ND license	本研究旨在评估缅甸在武装冲突、新冠疫情失控和经济崩溃“三重危机”下的人口心理健康负担、医疗需求及相关风险因素。通过对全国随机样本进行调查，结果显示超过三分之一成年人报告存在可能的心理障碍，其中可能的创伤后应激障碍、抑郁和焦虑患病率分别为一定比例。分析表明，高达近八成的可能创伤后应激障碍可归因于政治压力，若消除该压力，可减少数百万成人患者。据估计，约有数百万成年人可能需要寻求心理健康服务。研究结论指出，缅甸的心理健康负担极为沉重，只有三重危机结束后人口心理健康才有可能恢复，加速和平进程对于保护缅甸民众的心理健康至关重要。	2024	http://dx.doi.org/10.1016/j.lansea.2024.100396
Shah, TF; Li, J; Shah, ZH; Lu, YL; Qin, WH	Complete genome sequence of a novel fimH32 variant Escherichia coli LD91-1 ST1737, recovered from a hepatitis B patient in Yangon, Myanmar	从缅甸仰光一名乙肝患者体内分离出的新型大肠杆菌LD91-1 ST1737菌株，其完整基因组序列已测序完成	MICROBIAL PATHOGENESIS	Objectives: In this study, we report the complete genome sequence of a multidrug-resistant Escherichia coli LD91-1 recovered from a 57-year-old hepatitis B patient in Myanmar. Methods: E. coli LD91-1 was subjected to antimicrobial susceptibility testing. Extracted genomic DNA from the E. coli LD91-1 clone was sequenced using a Nanopore PromethION sequencer (ONT, UK) and the highthroughput Illumina HiSeq 2500 platform. The clean reads were de novo assembled using Flye (v.2.9). The complete genome was annotated using MLST, phylogeny, serotyping, plasmid replicons, fimH typing, chromosomal point mutations, antibiotic resistance, and virulence genes using web tools available at the Center for Genomic Epidemiology. Results: E. coli LD91-1 had a circular genome of 4,838,891 bp. In silico analysis revealed that E. coli LD91-1 comprised plasmid pLD91-1 and belonged to the ST1737-O22:H16 serotype carrying a fimH32 variant that had not been reported in such strains. Core genome phylogeny demonstrated clear divergence among major E. coli clades. Mutations in the quinolone resistance-determining regions gyrA, gyrB, parC, and parE conferred fluoroquinolone resistance; mutations in pmrA and pmrB conferred colistin resistance. Cephalosporin, fluoroquinolone, and tetracycline resistance genes were located on plasmid pLD91-1. Notably, several virulence genes, including 12 encoding yersiniabactin and yersiniabactin siderophores were also revealed in the E. coli LD91-1 genome. Conclusions: To our knowledge, this is the first complete genome report of a new E. coli LD91-1 carrying the fimH32 variant in Myanmar. This MDR E. coli isolate may pose potential risks to human and animal health, highlighting the urgent need for control and preventive strategies.	本研究报告了从缅甸一名肝炎患者体内分离出的多重耐药大肠杆菌LD91-1的全基因组序列。该菌株基因组为环状，经分析属于ST1737-O22:H16血清型，携带此前未见报道的fimH32变异型。核心基因组系统发育分析显示该菌株与主要大肠杆菌分支存在明显差异。喹诺酮耐药决定区的突变赋予了氟喹诺酮耐药性，而pmrA和pmrB突变则与黏菌素耐药相关。头孢菌素、氟喹诺酮和四环素耐药基因均位于质粒上。此外，基因组中还发现多个编码耶尔森菌素及其铁载体的毒力基因。本研究是缅甸首次报道携带fimH32变异型的大肠杆菌LD91-1完整基因组，该多重耐药菌株对人类和动物健康构成潜在风险，亟需采取控制和预防策略。	2025	http://dx.doi.org/10.1016/j.micpath.2025.108088